Workflow Automation

G-KnowMe specializes in creating custom automated pipelines for multiplex data analysis, streamlining the process for scientists to gain insights from their experiments. The variant prioritization and interpretation workflow for clinical reporting on next-generation sequencing-based tests is complex, requiring extensive analysis of large databases and literature. To address this, G-KnowMe has developed natural language processing-driven workflows that assist scientists in the clinical interpretation and reporting for these tests.

Assay Research and Development

CRISPR-BITS, a cutting-edge healthcare company, was recently launched by five BITS Pilani alumni. The company's goal is to harness CRISPR (clustered regularly interspaced palindromic repeats) technology to develop impactful solutions in healthcare, agro-biotech, and the food industry. G-KnowMe is the exclusive technical partner for this project, focusing on developing the CRISPR platform and various products in the diagnostics and biotechnology domains for both infectious diseases and cancer.

Risk Prediction Model Building

G-KnowMe provided services to a cancer diagnostics lab towards creating a prognostic test for predicting the risk of recurrence in triple-negative breast cancer (TNBC) patients using immunohistochemistry (IHC) biomarkers and machine learning techniques. Rigorous validation and statistical analysis were conducted to evaluate the applicability and performance of the developed models. This led to the identification of tumor and patient profiles that required additional data collection for accurate risk prediction.

Software Consulting

Manthan, an international web based platform to facilitate academia-industry partnerships in science and technology, is an initiative by the Office of the Principal Scientific Advisor to the Government of India. InDx, the Indigenisation of Diagnostics, is a national project launched by the Government of India and anchored at CCAMP Bangalore, to maintain a robust supply-chain network for Indian companies producing reagents. G-KnowMe has provided informatics consulting for both the initiatives, and has assisted requirements analysis, design, and development of the scalable and secure world class software platforms.

Clinical Data Management

Our team provided the guidance and technology support to develop an integrated oncology database using common data format that could collate diverse patient data from a variety of sources. The team worked closely with domain experts and informatics specialists of the client organization to develop the common data format, create comprehensive vocabularies using domain expertise in oncology, develop automated data extraction protocol using NLP and tested the database with real world data and problems.